Yes and no. If you have a large amount of activity against both data sets, then you are most likely churning your data cache. Take a look at your page life expectancy along with your cache hit ratio, compiles/recompiles, and buffer sizes. If you have a very low page life expectancy less than 20000, then you are most likely ejecting pages frequently from the data cache and are having to access that data directly from disk. It is very difficult to diagnose a problem such as this without have a lot of PerfMon data along with SQL Server traces and other statistics from the server.
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